By Eveline S. Litscher, Paul M. Wassarman
This e-book presents a coherent, transparent, and uniform presentation of structural, genetic, molecular, and biochemical details on hand for the zona pellucida area protein relations, which effect pathologies akin to infertility, deafness, and melanoma. moreover it:
- Details information regarding the constitution and serve as of the ZP area in ZPDC-proteins
- Provides illustrations of the association of ZPDC-proteins, the genes that encode the proteins, and examples of mutations within the ZP area that reason diseases
- Speculates as to the evolution of the ZP area and strength therapeutics for ailments stemming from ZP area mutations
- Addresses mammalian and non-mammalian systems
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Additional resources for A Guide to Zona Pellucida Domain Proteins
Kinloch RA, Ruiz‐Seiler B, Wassarman PM. Genomic organization and polypeptide primary structure of zona pellucida glycoprotein hZP3, the hamster sperm receptor. Devel Biol 142, 414–421 (1990). d Rabbit The rabbit (Oryctolagus cuniculus) ZP consists of four proteins, called ZP1–4. zp2, 3, and 4 have been characterized by cDNA cloning and sequencing and ZP1 by mass spectrometry. 1). ZP1: The polypeptide of ZP1 consists of 627 aa residues and has an SS (aa 1–20; highlighted), a trefoil domain (aa 217–257; italicized) with six Cys residues (aa 219, 228, 238, 243, 244, 253; capitalized and underlined), a ZPD (aa 262–531; highlighted) with 10 Cys residues (aa 263, 297, 316, 359, 440, 461, 513, 518, 526, 530; capitalized and underlined), followed by a CFCS (aa 536–539, KRRR; highlighted and underlined) and a TMD (aa 586–608; highlighted).
3). The EHP is part of β‐strand G and faces directly the IHP on β‐strand A of the ZP‐C sub‐domain. Apparently this arrangement is stable in the uncleaved protein precursor but dissociates slowly after cleavage at the CFCS. The structure is consistent with the idea that the EHP blocks premature protein assembly by acting as “molecular glue” that keeps the ZPD module in a conformation that is essential for secretion but is incompatible with assembly. 18 ZONA PELLUCIDA DOMAIN PROTEINS Further Reading Callebaut IU, Mornon AP, Monget P.
21 22 Mammalian Zona Pellucida Proteins 5. ZP proteins have an SS at the N‐terminus of the polypeptides, a CFCS and TMD downstream of the ZPD close to the C‐terminus of the polypeptides, and an IHP and EHP. 6. The CFCS of ZP1, 2, and 4 is only 1–4 aa downstream of the ZPD, whereas the CFCS of ZP3 is 28–45 aa downstream of the ZPD. j), aa sequences of ZP1–4 polypeptides for 12 mammalian species, from platypus (monotremes), to possum (marsupials), to human (placental mammals) are provided. 2 Monotremes Monotremes (Prototheria) are a mammalian sub‐class that includes the platypus and four species of echidnas (spiny anteaters) that lay eggs instead of giving birth to live young.