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By Carol Bernstein, Harris Bernstein

Why organisms age and why sexual replica exists are significant unsolved difficulties in biology. This publication offers an built-in rationalization of getting older and intercourse in line with present wisdom of DNA harm and service. Key beneficial properties* Discusses the universality of the matter of DNA harm* Describes getting older by reason of amassed DNA harm* Considers meiosis as an variation for DNA fix* Discusses mating in Read more...

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1971), the advantages of removing D N A d a m a g e s may be insufficient to select for a higher repair capacity in such cells. I I I . Accumulation and Neuronal of DNA Tissue Damage in Adult Muscle A. Muscle W e discuss here five studies of accumulation of D N A damage in muscle with age. T h e s e studies are also summarized in Table IV. {\91\) examined the template activity of D N A in sections of ethanol-fixed heart muscle fibers, as well as brain and liver tissues, from young ( 3 - 4 mo) and old (30-35 mo) mice.

N a k a n i s h i et al. (1979) used touch smears of brain cells and liver cells of young (4 wk) and senescent (1 yr) mice. The smears w e r e stained with antibody to cytidine nucleoside by an indirect immunofluorescence t e c h n i q u e . T h e antibody reacts only with denatured or single-stranded D N A . Cellular D N A binding by the antibody was only seen in the brain and liver tissues of aged animals, indicating the p r e s e n c e of single-stranded D N A d a m a g e s . N o such D N A damages w e r e detected in the epithelial cells of the gastrointestinal tract at any age.

B. (1972). The kinetics of degradation of DNA and RNA by H 0 . Biochim. Biophys. Acta 272, 539548. , and Ames, Β. N. (1975). Detection of carcinogens as mutagens in the Salmonella/microsome test: Assay of 300 chemicals. Proc. Natl. Acad. Sei. USA 72, 5135-5139. , and Ames, Β. N. (1988a). 7-Methylguanine adducts in DNA are normally present at high levels and increase on aging: Analysis by HPLC with electrochemical detection. Proc. Natl. Acad. Sei. USA 85, 7467-7470. , and Ames, Β. N. (1988b). Correction.

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