Download Alternative Splicing and Disease (Progress in Molecular and by Philippe Jeanteur PDF

By Philippe Jeanteur

Splicing of fundamental RNA transcript is a quasi-systematic step of gene expression in better organisms. this is often the 1st booklet to spotlight the scientific implications, i.e. illnesses, brought on by replacement splicing. substitute splicing not just greatly raises protein range but in addition bargains a number of possibilities for aberrant splicing occasions with pathological outcomes. The e-book additionally outlines attainable goals for treatment.

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Additional info for Alternative Splicing and Disease (Progress in Molecular and Subcellular Biology)

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1991) Baudry et al. (2000) Ge et al. (2000) Kwabi-Addo et al. (2001) Lin et al. (1998) NOS Ich-1 ischemia Catania et al. (2001) Daoud et al. 1 Gene Transfer Methods Type I and II mutations either destroy splice sites or activate cryptic splice sites. Antisense nucleic acids can suppress point mutations and promote the formation of the normal gene products. Special chemistries were devised to prevent RNAseH-mediated cleavage of the RNA and to lower toxicity (Sazani and Kole 2003). Oligonucleotides have been used to target cryptic splice sites that are activated in beta thalassemias (Lacerra et al.

Nature 409: 860–921 Le K, Mitsouras K, Roy M, Wang Q, Xu Q, Nelson SF, Lee C (2004) Detecting tissue-specific regulation of alternative splicing as a qualitative change in microarray data. Nucleic Acids Res 32: e180 Lee C, Wang Q (2005) Bioinformatics analysis of alternative splicing. Brief Bioinform. 6: 23–33. Levitin F, Baruch A, Weiss M, Stiegman K, Hartmann ML, Yoeli-Lerner M, Ziv R, Zrihan-Licht S, Shina S, Gat A, Lifschitz B, Simha M, Stadler Y, Cholostoy A, Gil B, Greaves D, Keydar I, Zaretsky J, Smorodinsky N, Wreschner DH (2005) A novel protein derived from the MUC1 gene by alternative splicing and frameshifting.

Hum Mol Genet 13: 1535–1549 Relogio A, Ben-Dov C, Baum M, Ruggiu M, Gemund C, Benes V, Darnell RB, Valcarcel J (2005) Alternative splicing microarrays reveal functional expression of neuron-specific regulators in Hodgkin lymphoma cells. J Biol Chem 280: 4779–4784 44 Tatyana Novoyatleva et al. Rizzu P, Van Swieten JC, Joosse M, Hasegawa M, Stevens M, Tibben A, Niermeijer MF, Hillebrand M, Ravid R, Oostra BA, Goedert M, van Duijn CM, Heutink P (1999) High prevalence of mutations in the microtubule-associated protein tau in a population study of frontotemporal dementia in the Netherlands.

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