By Philippe Jeanteur
Splicing of fundamental RNA transcript is a quasi-systematic step of gene expression in better organisms. this is often the 1st booklet to spotlight the scientific implications, i.e. illnesses, brought on by replacement splicing. substitute splicing not just greatly raises protein range but in addition bargains a number of possibilities for aberrant splicing occasions with pathological outcomes. The e-book additionally outlines attainable goals for treatment.
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Additional info for Alternative Splicing and Disease (Progress in Molecular and Subcellular Biology)
1991) Baudry et al. (2000) Ge et al. (2000) Kwabi-Addo et al. (2001) Lin et al. (1998) NOS Ich-1 ischemia Catania et al. (2001) Daoud et al. 1 Gene Transfer Methods Type I and II mutations either destroy splice sites or activate cryptic splice sites. Antisense nucleic acids can suppress point mutations and promote the formation of the normal gene products. Special chemistries were devised to prevent RNAseH-mediated cleavage of the RNA and to lower toxicity (Sazani and Kole 2003). Oligonucleotides have been used to target cryptic splice sites that are activated in beta thalassemias (Lacerra et al.
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